A Case Report: Obsessive Compulsive Disorder Induced by Isotretinoin Treatment

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Keywords:

isotretinoin, obsessive-compulsive disorder, case report, drug-induced OCD, neuropsychiatric side effects

Abstract

In this article, the emergence and treatment process of obsessions with pollution and cleaning compulsions in a 20-year-old female patient with a familial history of OCD and isotretinoin (40 mg/day for 5 months) use are described. OCD symptoms related to isotretinoin use have been reported in the literature. The aim of this case report is to emphasize the importance of psychiatric examination in patients who are started or considered to be started on isotretinoin.

References

1- Paichitrojjana A. Oral Isotretinoin and Its Uses in Dermatology: A Review. Drug Des Devel Ther . 2023;17:2573-2591. https://doi.org/10.2147/DDDT.S427530

2- Karadag, Ayse S. Systemic Isotretinoin Turkderm. 2020;54:34-40. DOI: 10.4274/Turkderm.Galenos.2020.23356

3- Stanojkovic T, Zivkovic Zaric R, Lesnjak I, Gajic M, Markovic S, Canovic A, Jankovic Jovanovic K. Treatment of Acute Psychosis Caused by Isotretinoin: Systematic Review. Psychiatry Clin Psychopharmacol. 2024 Jun 1;34(2):103-108. doi: 10.5152/pcp.2024.23778.

4- Jensen KV, Abba-Aji A. Isotretinoin-Induced Delusional Disorder, Somatic Subtype. Case Rep Dermatol Med. 2020 Jul 25;2020:8853167. doi: 10.1155/2020/8853167.

5- Alamri A, Khafaji R, Balkhy A, Samarkandy S, Alraddadi A. The Psychological Impact of Isotretinoin Therapy on Acne Vulgaris Patients. Cureus. 2023 Dec 16;15(12):e50612. doi: 10.7759/cureus.50612.

6- Danışmant B, Sağlam E, Tosuner C, Tarhan N. Isoretinoin therapy and obsessive-compulsive disorder: Case report. Klinik Psikofarmakoloji Bülteni 2012;22(Ek Sayı 1):S159

7- Bremner JD, Narayan M, Anderson ER, Staib LH, Miller H, Charney DS, 2000. Hippocampal volume reduction in major depression. Am. J. Psychiatry 157, 115-117.

8- Wang L, Chen Y, Wang M, Zhao C, Qiao D. Relationship between gene-environment interaction and obsessive-compulsive disorder: A systematic review. J Psychiatr Res. 2023;164:281-290. doi:10.1016/j.jpsychires.2023.06.004

9- Yesilova Y, Bez Y, Arı M, Kaya M, Alpak G. Effects of isotretinoin on obsessive compulsive symptoms, depression, and anxiety in patients with acne vulgaris. Journal of Dermatological Treatment. 2012; 23: 268-271. DOI:10.3109/09546634.2011.608782

10- Kose S, Akin E, Cetin M. Adverse drug reactions and causality: the Turkish version of Naranjo Adverse Drug Reactions Probability Scale, Psychiatry and Clinical Psychopharmacology. 2017;27:2, 205-206. DOI:10.1080/24750573.2017.1332512

11- American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 5th edition. Washington, DC, American Psychiatric Association, 2013.

12- Rasmussen SA, Eisen JL: Epidemiology and clinical features of obsessive-compulsive disorder. Psychiatr Clinic North America 1992; 15: 743-758.

13- Öztürk, O., & Uluşahin, A. (2022). Mental Health and Disorders [Ruh Sağlığı ve Bozuklukları]. Nobel Tıp Kitabevleri.

14- Mataix-Cols D, Boman M, Monzani B, et al. : Population-based, multigenerational family clustering study of obsessive-compulsive disorder. JAMA Psychiatry 2013; 70:709-717.

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20.09.2025 — Updated on 05.10.2025

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